Effect of Remote Ischemic Preconditioning on Incidence of Atrial Fibrillation in Patients Undergoing Coronary Artery Bypass Graft Surgery

Status unconfirmed · Phase 3 · Has a placebo group

Conditions studied: Atrial Fibrillation

In brief

Atrial fibrillation is the most common arrhythmic complication after coronary artery bypass grafting (CABG). Post operative atrial fibrillation (POAF) increases morbidity and mortality. Inflammation could be a factor in POAF and recent evidence of remotely inducing ischemia may reduce inflammation and cardiac injury. The investigators plan to use a blood pressure cuff on the arm as a method to produce remote ischemia and assess the occurrence of POAF for seven day.

Key facts

Study ID

NCT01500369

Run by

Baystate Medical Center

People needed

410

Starts

2010-12-01

Expected to finish

2015-06-01

Last updated by the study team

2013-07-03

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• This will be a prospective randomized controlled study on patients older than 18 years old who are undergoing elective CABG with or without valve surgery.

You may not qualify if…

• any preoperative rhythm other than sinus,
• history of atrial fibrillation,
• New York Hear Association (NYHA) IV congestive heart failure,
• cardiogenic shock,
• emergent CABG and/or valve surgery,
• bleeding diathesis, and
• women of child-bearing potential. Eligible patients will participate after obtaining consent.

Where it is running

• Baystate Medical Center — Springfield, Massachusetts, United States (enrolling)

Full record on ClinicalTrials.gov

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