Effects of Calorie Restriction on Accumulation of Old, Modified Proteins in Abdominally Obese Adults

Completed · Not applicable

Conditions studied: Insulin Resistance

In brief

This study is being done to understand the effects of calorie restriction and weight loss on muscle protein metabolism in adult men and women.

Key facts

Study ID

NCT01497106

Run by

Mayo Clinic

People needed

29

Starts

2011-12-01

Expected to finish

2014-11-01

Last updated by the study team

2014-11-26

Who can join

Age: 45 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy
• BMI will be between 30 kg/m2 - 38 kg/m2 and waist circumference for women ≥ 88 cm and men ≥ 104 cm
• Age 45 to 65 years.
• Male and Female

You may not qualify if…

• Active coronary artery disease
• BMI < 30 kg/m2 Participation in structured exercise (>2 times per week for 30 minutes or longer)
• Smoking
• Medications known to affect muscle metabolism (beta blockers)
• Renal failure (serum creatinine > 1.5mg/dl)
• Chronic active liver disease (AST and ALT > 3 times normal)
• Fasting blood glucose > 126 mg/dl
• Anti-coagulant therapy (warfarin/heparin)

Where it is running

• Mayo Clinic — Rochester, Minnesota, United States

Full record on ClinicalTrials.gov

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