Multicenter Perioperative Opioid Pharmacogenetic Study

Completed

Conditions studied: Pain

In brief

The purpose of this research study is to identify factors and genes (the DNA material that determines the makeup of the human body) that may be associated with how children respond to pain medication. Specifically, the investigators want to study factors that may be associated with pain sensitivity, morphine requirement after surgery and side-effects from morphine and other pain medications. The investigators expect that the information obtained in this research study will help us to develop more effective, safe, and tailored treatment options in the future.

Key facts

Study ID

NCT01495611

Run by

Children's Hospital Medical Center, Cincinnati

People needed

1000

Starts

2010-11-01

Expected to finish

2017-04-30

Last updated by the study team

2017-01-31

Who can join

Age: 6 and older, up to 17. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• children 6-17 years of age
• ASA physical status 1 and 2
• scheduled for tonsillectomy (T) and tonsillectomy and adenoidectomy (T and A)
• Children with obstructive sleep apnea will also be included.

You may not qualify if…

• children with developmental delay
• liver and renal diseases,
• preoperative pain requiring analgesics (e.g. chronic tonsillitis).

Where it is running

• Children's Hospital of Los Angeles — Los Angeles, California, United States
• Stanford University Medical Center — Palo Alto, California, United States
• The Children's Hospital, Denver — Denver, Colorado, United States
• University of Miami - Miller School of Medicine — Miami, Florida, United States
• Children's Memorial Hospital — Chicago, Illinois, United States
• Ochsner Medical Center for Children — New Orleans, Louisiana, United States
• The Johns Hopkins Hospital — Baltimore, Maryland, United States
• Boston Children's Hospital — Boston, Massachusetts, United States
• C.S. Mott Children's Hospital — Ann Arbor, Michigan, United States
• St. Louis Children's Hospital — St Louis, Missouri, United States
• Cincinnati Children's Hospital Medical Center — Cincinnati, Ohio, United States
• St. Christopher's Hospital for Children — Philadelphia, Pennsylvania, United States
• Texas Children's Hospital — Houston, Texas, United States
• Seattle Children's Hospital — Seattle, Washington, United States
• UW Health-American Family Children's Hospital — Madison, Wisconsin, United States

Full record on ClinicalTrials.gov

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