Evaluation of a Dry Powder Aerosol Dispersion Mechanism by Radiolabeling Techniques

Completed · Not applicable

Conditions studied: Adult Healthy Volunteers

In brief

The primary objective is to admix a radiolabel with albuterol sulphate for incorporation into the Handihaler® device for inhalation studies. This will allow for the investigators to determine the regional lung deposition of drug inhaled from the standard Handihaler® device compared to a novel modification of the device to provide more effective dispersion and aerosolization of the coated albuterol powder. The new mechanism of action for proof-of-concept testing consists of a bead (5.1 mm; expanded polystyrene foam) coated with drug powder, as opposed to the standard lactose formulation-filled capsule.

Key facts

Study ID

NCT01495442

Run by

University of North Carolina, Chapel Hill

People needed

6

Starts

2011-12-01

Expected to finish

2012-06-01

Last updated by the study team

2017-01-24

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• healthy volunteers adults

You may not qualify if…

• chronic illness

Where it is running

• University of North Carolina at Chapel Hill, CEMALB — Chapel Hill, North Carolina, United States

Full record on ClinicalTrials.gov

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