Combined Donepezil and Selegiline Effects on Cocaine-Reinforced Behavior

Completed · Phase 2 · Has a placebo group

Conditions studied: Cocaine Use Disorders

In brief

No medications are currently available for treatment of psychostimulant addiction, a compulsive preoccupation with use of cocaine and related compounds. Donepezil is a medication that is currently prescribed for Alzheimer's disease, and selegiline is a medication used for treatment of Parkinson's Disease. Both of these medications can decrease the amount of cocaine injections that laboratory animals choose to inject by vein. This project will determine if combined treatment with donepezil and selegiline can also decrease cocaine-motivated behavior for human subjects in a laboratory setting.

Key facts

Study ID

NCT01495195

Run by

Midwest Biomedical Research

People needed

12

Starts

2012-02-01

Expected to finish

2013-05-01

Last updated by the study team

2013-12-18

Who can join

Age: 21 and older, up to 50. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Meets DSM-IV-TR criteria for cocaine abuse or dependence
• At least one cocaine-positive urine within 6 weeks prior to enrollment
• Has used cocaine for a duration of at least 6 months
• At least weekly cocaine use during the last 30 days

You may not qualify if…

• History of a medical adverse reaction to cocaine or other psychostimulants
• Any current Axis I psychiatric disorder other than drug abuse or dependence
• Dependence on abused substances other than cocaine
• Current or past history of seizure disorder
• Heart or lung disease

Where it is running

• Kansas City VA Medical Center — Kansas City, Missouri, United States

Full record on ClinicalTrials.gov

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