Efficacy of Tyrosine in Restless Legs Syndrome
Completed · Not applicable
Conditions studied: Restless Legs Syndrome (RLS)
In brief
Tyrosine is a non essential amino acid that is the precursor of the neurotransmitter, dopamine. Tyrosine is converted into Levodihydrophenylalanine (L-Dopa) and L-Dopa is subsequently and avidly converted into dopamine. It is well known that dopamine deficiency leads to the manifestations of restless legs syndrome (RLS). Studies have shown dopamine agonists and L-dopa to be effective in controlling symptoms. No studies to date have been done to determine the role of tyrosine in RLS. This open-label pilot study aims to determine the efficacy and tolerability of tyrosine in RLS, as current agents have limitations in treating RLS in addition to adding another possible agent to the investigators arsenal of treating RLS that maybe more cost efficient. In this pilot study, the dose of tyrosine will be escalated from 750 mg once daily by mouth (PO) up to 3000 mg once daily PO, as tolerated, in increments of 750 mg every week in patients who meet the inclusion criteria for RLS. Patients' symptoms will be monitored on a weekly basis for six weeks.
Key facts
- Study ID
- NCT01494766
- Run by
- Seton Healthcare Family
- People needed
- 5
- Starts
- 2012-01-01
- Expected to finish
- 2012-11-01
- Last updated by the study team
- 2017-04-27
Who can join
Age: 18 and older, up to 80. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Men and women aged 18 to 80 years and
- Newly diagnosed (medication-naïve) as having restless legs syndrome (using the International Restless Legs Syndrome Study Group (IRLSSG20) diagnostic criteria with a score of greater than or equal to 15, see Appendix A) and
- That interfered with sleep onset and/or maintenance for greater than four nights/week for a minimum of six months
- Currently not receiving treatment for RLS
You may not qualify if…
- Patients suffering from secondary RLS (other movement and/or primary sleep disorders, chronic renal insufficiency - calculated from the creatinine clearance, and/or iron deficiency - baseline serum ferritin level less than 10 ng/ml)
- Patients currently on pharmacotherapy for RLS (not medication-naïve) or previous use of pharmacotherapy for RLS in the past
- Patients that are pregnant and/or breastfeeding
- Patients that are on levothyroxine or monoamine oxidase inhibitors
Where it is running
- Seton Family of Hospitals — Austin, Texas, United States
Full record on ClinicalTrials.gov
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