Registry for the Atopic Dermatitis Research Network

Completed

Conditions studied: Atopic Dermatitis, Eczema Herpeticum

In brief

The purpose of this multi-center, clinical registry study is to determine genetic markers associated with susceptibility of AD patients to infections and to also serve as a potential participant database for future studies.

Key facts

Study ID

NCT01494142

Run by

National Institute of Allergy and Infectious Diseases (NIAID)

People needed

3387

Starts

2011-08-01

Expected to finish

2018-02-07

Last updated by the study team

2018-09-19

Who can join

Age: 1 and older, up to 80. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Participants who meet all of the following criteria are eligible for enrollment. Participants may be reassessed if not initially eligible.
• ADEH+ and Non-atopic males and females ages 8 months to 80 years, inclusive, at the time of Enrollment, and ADEH- males and females ages 3 years to 80 years, inclusive, at the time of Enrollment.
• Who are willing to sign the informed consent form or whose parent or legal guardian is willing to sign the informed consent form (age appropriate) prior to initiation of any study procedures.
• Who are willing to sign the assent form, if age appropriate.
• Who meet criteria for one of the diagnostic groups (ADEH-Staph+, ADEH-Staph-, ADEH+, ADEV+, Non-atopic) as defined in the ADRN Standard Diagnostic Criteria and the Staphylococcus aureus Colonization Criteria.

You may not qualify if…

• Participants who meet any of the following criteria are not eligible for enrollment.
• Who have an active systemic malignancy; uncomplicated non-melanoma skin cancer and melanoma in situ with documentation of complete excision are not exclusionary.
• Who have any skin disease other than AD that might compromise the stratum corneum barrier (e.g., bullous diseases, psoriasis, cutaneous T cell lymphoma [also called Mycosis Fungoides or Sezary syndrome], dermatitis herpetiformis, Hailey-Hailey, or Darier's disease).
• Who have a history of systemic immunological illness (e.g., immunodeficiency disorders such as human immunodeficiency virus [HIV] or lupus erythematosus) other than the condition being studied.
• Who have a first degree relative already enrolled in the study.
• Who are determined not to be eligible in the opinion of the Investigator.

Where it is running

• Children's Hospital Los Angeles — Los Angeles, California, United States
• National Jewish Health — Denver, Colorado, United States
• Northwestern University — Chicago, Illinois, United States
• Ann & Robert H. Lurie Children's Hospital of Chicago — Chicago, Illinois, United States
• Boston Children's Hospital — Boston, Massachusetts, United States
• Icahn School of Medicine at Mount Sinai — New York, New York, United States
• University of Rochester Medical Center — Rochester, New York, United States
• Oregon Health & Science University — Portland, Oregon, United States
• Children's Hospital of Philadelphia — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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