BETERNet Notch Signaling and Novel Biomarkers for Barretts Esophagus

Completed

Conditions studied: Barrett's Esophagus

In brief

This research study hopes to identify new molecular markers in the tissue of Barrett's esophagus that will help physicians better understand and manage this condition. Patients undergoing an upper endoscopy will be asked to complete a gastroesophageal reflux disease (GERD) questionnaire, provide a blood sample and allow additional biopsies to be taken during the procedure.

Key facts

Study ID

NCT01484925

Run by

Abramson Cancer Center at Penn Medicine

People needed

60

Starts

2011-11-01

Expected to finish

2018-11-01

Last updated by the study team

2019-12-05

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• For BE patients:
• History of histologically confirmed BE, defined as endoscopically-suspected BE with intestinal metaplasia with globlet cells on esophageal biopsies,
• BE length C1M1 or C0M2
• Age 18 years

You may not qualify if…

• History of gastric or esophageal surgery
• Inability to give informed consent
• Erosive esophagitis seen on upper endoscopy
• History of prior endoscopic therapy for BE 5 (for controls) History of intestinal metaplasia on previous esophageal, GE junction or cardia biopsies.

Where it is running

• Abramson Cancer Center — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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