A Human Proof of Concept Study for [11C]-RO5011232 as Radiotracer and Study of the Binding of RO4917523 to Human mGlu5 Brain Receptor at Steady-State in Healthy Volunteers
Completed · Phase 1
Conditions studied: Healthy Volunteer
In brief
This open label, non-randomized, parallel group study will evaluate \[11C\]-RO5011232 as radiotracer for brain mGlu5 receptor occupancy and investigate the binding of RO49917523 to human mGlu5 brain receptor at steady-state in healthy volunteers. In Parts I, II and III, positron emission tomography (PET) assessments of specific uptake of the radiotracer and whole body dosimetry will be made after intravenous injection of \[11C\]-RO5011232. In Part IV, subjects will receive RO4917523 orally daily for 14 days while receiving three single intravenous bolus injections of \[11C\]-RO5011232. The anticipated time on study treatment is up to 4 weeks.
Key facts
- Study ID
- NCT01483469
- Run by
- Hoffmann-La Roche
- People needed
- 56
- Starts
- 2011-12-01
- Expected to finish
- 2013-10-01
- Last updated by the study team
- 2016-11-02
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Healthy male and female volunteers as determined by medical history, physical examination, 12-lead ECG, and routine clinical laboratory measurements
- Age 18 to 65 years inclusive
- Body mass index (BMI) between 18 to30 kg/m2 inclusive and body weight at least 50 kg
- Appropriate body size (less than 195 cm [6 feet and 5 inches]) in order to accommodate the whole body scanning
You may not qualify if…
- History of or presence of clinically significant psychiatric condition, as evaluated by a psychiatrist before enrolment
- History of head trauma with prolonged loss of consciousness (>10 minutes) or any neurological condition or a history of migraine headaches
- Contraindications to MRI procedures (Part I, III and IV)
- Subjects suffering from claustrophobia or who would be unable to undergo magnetic resonance imaging (MRI) or PET scanning
- Positive pregnancy test at screening or on any day preceding a PET scan
- Lactating women
- Positive for hepatitis B, hepatitis C or HIV infection
- Any history of alcohol or drug abuse within the last 6 months
- Regular smoker or nicotine user (>10 cigarettes per day)
- Participation in an investigational drug or device study within three months prior to screening
Where it is running
- Study site — Baltimore, Maryland, United States
- Study site — Baltimore, Maryland, United States
Full record on ClinicalTrials.gov
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