A Dose Evaluation Study of the Effect of Plug Placement on the Efficacy and Safety of the Latanoprost Punctal Plug Delivery System (L-PPDS) in Subjects With Ocular Hypertension or Open-Angle Glaucoma

Completed · Phase 2

Conditions studied: Glaucoma, Ocular Hypertension (OH)

In brief

The purpose of this study is to determine the effect of plug placement on the efficacy, safety and duration of effect of the L-PPDS (latanoprost punctal plug delivery system).

Key facts

Study ID: NCT01481077
Run by: Mati Therapeutics Inc.
People needed: 77
Starts: 2011-11-01
Expected to finish: 2012-09-01
Last updated by the study team: 2013-09-26

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Male or female at least 18 years old
Diagnosis of bilateral open angle glaucoma or ocular hypertension
Unmedicated IOP must be ≥22mm Hg

You may not qualify if…

Any significant vision loss in the last year
No contact lens use for the length of the study
Abnormal eye lids, eye infection or diseases to the eye
Recent eye surgery
Uncontrolled medical conditions

Where it is running

Vold Vision — Springdale, Arkansas, United States
Glaucoma Consultants of Colorado, PC — Denver, Colorado, United States
Danbury Eye Physicians & Surgeons — Danbury, Connecticut, United States
Ophthalmology Consultants Inc. — Des Peres, Missouri, United States
Ophthalmology Associates — St Louis, Missouri, United States
Comprehensive Eye Care, Ltd — Washington, Missouri, United States
Las Vegas Physicians Research Group — Henderson, Nevada, United States
Abrams Eye Institute — Las Vegas, Nevada, United States
Philadelphia Eye Associates — Philadelphia, Pennsylvania, United States
University Eye Surgeons — Maryville, Tennessee, United States
Total Eye Care, P.A. — Memphis, Tennessee, United States

Full record on ClinicalTrials.gov

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