Effects of Aerobic and Resistance Training on Accumulation of Old, Modified Proteins in Young and Older Adults
Completed · Not applicable
Conditions studied: Sarcopenia
In brief
Muscle proteins accumulate damage during aging and leads to the loss of muscle mass and function in older people. Exercise can increase the making of new proteins and removal of older proteins, but it is not known if the effect changes with aging or type of exercise. The investigators will determine the ability for endurance, resistance, or a combination of exercise training to remove older-damaged proteins and make newer-functional muscle proteins in groups of younger and older people. The investigators will particularly study protein that are involved with energy production (mitochondrial proteins) and force production (contractile proteins). Hypothesis 1: Older people will have greater accumulation of damaged proteins than younger people. Hypothesis 2: Aerobic exercise will decrease the accumulation of damaged forms of contractile and mitochondrial proteins in younger and older people. Hypothesis 3: Resistance exercise will decrease the accumulation of damaged forms of contractile proteins in younger and older people.
Key facts
- Study ID
- NCT01477164
- Run by
- Mayo Clinic
- People needed
- 72
- Starts
- 2011-11-01
- Expected to finish
- 2017-03-01
- Last updated by the study team
- 2017-08-08
Who can join
Age: 18 and older, up to 80. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Healthy
- 18 to 30 years or 65 to 80 years old
- Male and female
You may not qualify if…
- Regular exercise program
- Smoking
- Metabolic disease (diabetes, cardiovascular disease, cancer, thyroid disorders)
- Pregnancy
- Inability to exercise
- Overweight or obesity
- Drugs known to impair metabolic function (statin, beta-blocker, anti-inflammatory)
- Allergies to lidocaine
Where it is running
- Mayo Clinic — Rochester, Minnesota, United States
Full record on ClinicalTrials.gov
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