Systolic Pressure Intervention Trial Factors Affecting Factors Affecting Atherosclerosis Study

Completed

Conditions studied: Hypertension, Chronic Kidney Disease

In brief

Systolic Pressure Intervention Trial (SPRINT) is a large scale randomized trial of \~ 9250 adults aged 50 years or older with high cardiovascular risk sponsored by NIH. The study is designed to recruit 45% of the study population with Chronic Kidney Disease (CKD). The trial will test the effects of low systolic blood pressure (SBP) goal of \< 120 mm Hg versus the standard goal of \< 140 mm Hg on the primary composite of cardiovascular events and death. One of the pre-specified secondary outcome is the progression of kidney disease. In this ancillary named SPRINT - Factors affecting Atherosclerosis STudy (FAST), the investigators plan to take advantage of the unique opportunities afforded by the parent study to examine issues that are of significant public health importance. This is an observational study in SPRINT participants. This study will examine mechanistically, the factors affecting the progression of atherosclerosis in CKD.

Key facts

Study ID

NCT01475747

Run by

University of Utah

People needed

595

Starts

2011-09-01

Expected to finish

2018-12-01

Last updated by the study team

2019-01-04

Who can join

Age: 50 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Systolic Pressure Intervention Trial (SPRINT) participants

You may not qualify if…

• Contraindications to MRI (such as intracranial metal prostheses, weight > 300 pounds, claustrophobia and certain types of hardware used in pacemakers, prostheses, etc.)

Where it is running

• Stanford University — Palo Alto, California, United States
• University of Colorado Denver — Denver, Colorado, United States
• George Washington University — Washington D.C., District of Columbia, United States
• Mayo Clinic Jacksonville — Jacksonville, Florida, United States
• University of Minnesota — Minneapolis, Minnesota, United States
• Wake Forest University — Winston-Salem, North Carolina, United States
• Case Western Reserve University — Cleveland, Ohio, United States
• Cleveland Clinic — Cleveland, Ohio, United States
• University of Pennsylvania — Pittsburgh, Pennsylvania, United States
• University of Pittsburg — Pittsburgh, Pennsylvania, United States
• University of Utah — Salt Lake City, Utah, United States
• University of Washington — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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