Aprepitant Versus Ondansetron in Preoperative Triple-therapy Treatment of Nausea and Vomiting
Completed · Phase 4 · Has a placebo group
Conditions studied: Postoperative Nausea and Vomiting (PONV), Nausea
In brief
This study is being done to determine the efficacies of two preventative drug combinations for postoperative nausea and vomiting in patients undergoing neurosurgery. The aim of this study is to compare the efficacy of using aprepitant instead of ondansetron in combination with dexamethasone and promethazine for post-operative nausea and vomiting prophylaxis. By completing this comparison study investigators will determine the most efficacious drug combination which will allow us to enhance the overall comfort and satisfaction of neurosurgical patients in the immediate postoperative period.
Key facts
- Study ID
- NCT01474915
- Run by
- Sergio Bergese
- People needed
- 122
- Starts
- 2007-06-01
- Expected to finish
- 2013-04-01
- Last updated by the study team
- 2013-12-03
Who can join
Age: 18 and older, up to 85. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Adult patients
- 18 to 85 years of age
- Scheduled for neurosurgery requiring opening of the cranium and dura at Ohio State University Medical Center and who consent in writing to participate in this study are eligible.
You may not qualify if…
- Patients will be excluded from this study if they are
- prisoners
- pregnant women
- mentally ill
- under the age of 18 or over the age of 85
- American Society of Anesthesiologist (ASA) classification V
- alcohol or drug abusers
- have a cerebral perfusion pressure (CPP) greater than 150 mmHg or less than 50 mmHg.
Where it is running
- The Ohio State University Wexner Medical Center — Columbus, Ohio, United States
Full record on ClinicalTrials.gov
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