Intravenous Acetaminophen for Craniotomy Patients
Status unconfirmed · Phase 2
Conditions studied: Craniotomy
In brief
Adding intraoperative IV acetaminophen, in addition to standard analgesics, will decrease opioid requirements over the first 12 hours of postoperative recovery following craniotomy. Opioids exacerbate symptoms of nausea and vomiting. Reducing postoperative opioid use hopefully will reduce incidence of nausea and vomiting in patients after craniotomy.
Key facts
- Study ID
- NCT01474304
- Run by
- Swedish Medical Center
- People needed
- 80
- Starts
- 2011-11-01
- Last updated by the study team
- 2016-09-29
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- At least 18 years of age
- Weigh at least 50 kg (110.23 lbs)
- Undergoing open, elective intracranial procedure for
- tumor resection
- aneurysm clipping
- revascularization
- Have an ASA (American Society of Anesthesiologists) physical status of 1, 2, 3, or 4
- Able to provide written informed consent
You may not qualify if…
- Significant medical disease, laboratory abnormality, or condition that, in the opinion of the investigator, would compromise patient welfare or would otherwise contraindicate study participation
- Unable to communicate symptoms
- Current daily opioid use (>40 mg morphine equivalent)
- Tramadol use
- Treated with MAO (monoamine oxidase inhibitors) inhibitors within 10 days of surgery
- Treated with any amount of acetaminophen within 8 hours of anesthesia for surgery
- Allergic or hypersensitive to acetaminophen or any contraindications per manufacturer's guidelines
- Pregnancy
- Impaired liver function
- Participation in interventional clinical study within the last 30 days
- Known or suspected history of alcohol or drug abuse
- Surgery for resection of acoustic neuroma
- Transphenoidal tumor resection
Where it is running
- Swedish Medical Center Cherry Hill Campus — Seattle, Washington, United States (enrolling)
Full record on ClinicalTrials.gov
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