Study of Febuxostat Effect on Blood Pressure in Patients With High Normal Blood Pressure
Completed · Phase 4 · Has a placebo group
Conditions studied: Prehypertension, Gout, Pulse Wave Velocity, Hypertension, 24 Hour Blood Pressure
In brief
High normal blood pressure, also called prehypertension, is a significant problem. High uric acid in the blood, the same thing that causes gout, may cause higher blood pressures. The investigators plan to monitor the effects of the drug febuxostat(trade name Uloric) on blood pressure and stiffness of the main blood vessels and see if lowering uric acid has any effect.
Key facts
- Study ID
- NCT01472692
- Run by
- University of California, San Diego
- People needed
- 47
- Starts
- 2011-10-01
- Expected to finish
- 2014-03-01
- Last updated by the study team
- 2019-12-16
Who can join
Age: 18 and older, up to 50. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Prehypertensive male and female subjects with SBP =120-140 mmHg or DBP =80-90 mmHg (as determined by seated office BP).
- Plasma uric acid level ≥5 mg/dl
- Ages 18-50
- non-smokers
- Subjects will need to remain in the San Diego area for the duration of the study and be accessible by telephone or email.
You may not qualify if…
- no current smoking in the prior 6 months.
- Any history of any serious medical conditions requiring close monitoring from physicians- such as liver impairment, chronic kidney disease, or diabetes mellitus. Participants not currently under the care of a physician for these conditions will be eligible for the study.
- Any history of gout, hypertension, hypercholesterolemia, morbid obesity.
- Any history of use xanthine oxidase inhibitors, antihypertensives, antiglycemic, and cholesterol lowering medications
- any history of illicit drug use within the last 6 months
Where it is running
- Univerisity Of California San Diego — San Diego, California, United States
Full record on ClinicalTrials.gov
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