Treatment to Enhance Cognition in Bipolar Disorder

Completed · Not applicable

Conditions studied: Bipolar Disorder, Psychosis

In brief

The purpose of the present study is to evaluate a neuroplasticity-oriented, computer-based cognitive remediation treatment program in patients with bipolar disorder and its effects on cognitive deficits and community functioning compared to an active, computer-based control.

Key facts

Study ID

NCT01470781

Run by

Mclean Hospital

People needed

72

Starts

2011-06-01

Expected to finish

2016-08-01

Last updated by the study team

2026-04-03

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Clinical diagnosis of BD with psychosis
• Positive and Negative syndrome Scale (PANSS) < 75; PANSS Psychosis item scores = 3 or under; Young Mania Rating Scale (YMRS) = 6 or under
• Age between 18 and 50
• Within 10 years of illness onset
• Legal and mental competency of the participant

You may not qualify if…

• Age under 18 or over 50
• PANSS >75; PANSS Psychosis item scores >3; YMRS > 6
• Legal or mental incompetence (legal incompetence defined by any guardianship (including of person or treatment guardianship); mental incompetence defined by failure of the informed consent survey)
• Psychiatric inpatient status at time of enrollment
• Delirium secondary to medical illness
• Psychotic or mood disorder due to general medical or neurological illness
• History of head trauma
• History of seizure disorder or photo-sensitive seizures
• Use of anticholinergic medication, clozapine or olanzapine at baseline
• Rapid-cycling bipolar disorder
• Diagnosis of current substance abuse (past month) or substance dependence within the past year.

Where it is running

• McLean Hospital — Belmont, Massachusetts, United States

Full record on ClinicalTrials.gov

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