Oral Contraceptives and Subantimicrobial Doxycycline: Effect on Endometrial Matrix Metalloproteinases

Completed · Not applicable

Conditions studied: Breakthrough Bleeding

In brief

The purpose of this study is to compare the effects (good and bad) of subantimicrobial dose doxycycline on the irregular bleeding women experience when taking continuous oral contraceptive pills. This research is being done because currently, there is no effective treatment for this condition. Findings from this study could help to decrease the side effects of birth control pills and decrease unplanned pregnancies.

Key facts

Study ID

NCT01469585

Run by

University of Hawaii

People needed

20

Starts

2011-11-01

Expected to finish

2012-05-01

Last updated by the study team

2020-12-17

Who can join

Age: 18 and older, up to 45. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Women between the ages 18 and 45 who are ovulatory as demonstrated by a pre-treatment Progesterone (P) greater than or equal to 3.0 ng/mL prior to oral contraceptive use

You may not qualify if…

• Women with any absolute contraindications to ethinyl estradiol and levonorgestrel;
• Women who are pregnant or breastfeeding
• Use of oral contraceptives, patch, ring, intrauterine or implantable hormonal contraception within 4-weeks;
• Medroxyprogesterone acetate use within six months;
• Current use of drugs that interfere with sex steroid metabolism.

Where it is running

• Kapiolani Medical Center for Women and Children — Honolulu, Hawaii, United States

Full record on ClinicalTrials.gov

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