Bone Marrow Cell Engraftment of the Uterus and Genetic Studies of Reproductive Functioning

Completed

Conditions studied: Endometriosis, Stem Cell Transplant, Healthy Volunteers

In brief

Background: \- Some transplant recipients have been found to have cells in their uterus that come from the donor. Researchers want to study uterine tissue from three different groups of women: (1) healthy volunteers, (2) people who have had a stem cell transplant, and (3) people with rare diseases or conditions that affect reproduction. These samples will help researchers learn more about the way stem cells work in the reproductive tract. Objectives: \- To collect cells from the uterus to study how stem cells work in the reproductive tract. Eligibility: \- Women at least 18 years of age. Design: * Participants will be screened with a physical exam and medical history. They will also have blood and urine tests. * Participants will have an endometrial biopsy to collect cells for study. The biopsy visit will take 1 to 2 hours.

Key facts

Study ID

NCT01468935

Run by

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

People needed

79

Starts

2011-10-31

Expected to finish

2017-09-21

Last updated by the study team

2019-12-17

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: accepted.

You may not qualify if…

• Unable to comprehend the investigational nature of the protocol participation.
• Positive pregnancy test.
• Anticoagulation or known coagulopathy.
• Active gonorrhea or Chlamydia infections or pelvic inflammatory disease within the last 3 months.
• Previous hysterectomy or endometrial ablation procedure.
• Thrombocytopenia (<50,000).
• Uterine or cervical cancer.
• Cervical stenosis.

Where it is running

• National Institutes of Health Clinical Center, 9000 Rockville Pike — Bethesda, Maryland, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.