A Study of AC220 Given After Transplant in Subjects With Acute Myeloid Leukemia (AML)

Completed · Phase 1

Conditions studied: Leukemia, Myeloid, Acute

In brief

The purpose of this study is to define a safe dose of AC220 when given as maintenance therapy after treatment with an allogeneic stem cell transplant.

Key facts

Study ID: NCT01468467
Run by: Daiichi Sankyo
People needed: 13
Starts: 2012-04-01
Expected to finish: 2015-03-01
Last updated by the study team: 2019-02-12

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Subject has a diagnosis of acute myeloid leukemia (AML) according to WHO classification (2008) and has received a high dose or a reduced intensity conditioning allogeneic Hematopoietic Stem Cell Transplant (HSCT) during first or second remission and within 30 to 60 days prior to first dose of AC220. Donors may be human leukocyte antigen (HLA)-matched for HLA-A, B, C, DRB1, and DQB1 by high resolution typing, related or unrelated (only a single allele disparity will be allowed for HLA-A, B, or C as defined by high resolution typing) Note: more than one HSCT is allowed
Subject must be in morphologic remission (< 5% marrow blasts) and without active central nervous system (CNS) AML within 14 days prior to first dose of AC220
Subject must have CD3 donor chimerism > 50 % at Screening
Subject has a Karnofsky Performance Status (KPS) of ≥ 60
Subject must have absolute neutrophil count (ANC) > 1000/mm3 and platelet count > 50,000/mm3 without platelet transfusion support within 2 weeks prior to first dose
Subject must have adequate renal, hepatic, and coagulation parameters
Female subjects must not be lactating and must not be breastfeeding at Screening or during the study period and for 28 days [or five half lives of the study drug whichever is longer] after final study drug administration.
Subject is able to comply with study procedures and follow-up examinations

You may not qualify if…

Subject received AC220 and relapsed during treatment with AC220
Subject has active ≥ Grade 2 graft versus host disease (GVHD)
Subject has received concurrent chemotherapy, immunotherapy, or radio-therapy within 21 days prior to the first dose of AC220, or any antineoplastic therapy that is considered to be investigational (i.e., used for non-approved indications(s) and in the context of a research investigation) within 30 days or 5 half-lives (whichever is longer) prior to the first dose of study drug
Subject requires treatment with concomitant drugs that prolong QT/QTc interval or strong cytochrome P-3A4 (CYP3A4) inhibitors or inducers with the exception of immunosuppressants, antibiotics, antifungals, and antivirals that are used as standard of care post-transplant or to prevent or treat infections and other such drugs that are considered absolutely essential for the care of the subject
Subject requires treatment with anticoagulant therapy
Subject has a known positive test for human immunodeficiency virus, hepatitis C, or hepatitis B surface antigen
Subject had major surgery within 4 weeks prior to first dose of AC220
Subject has uncontrolled or significant cardiovascular disease
Subject has an active acute fungal, bacterial, or other infection that is unresponsive to therapy
Subject has participated in any interventional clinical study or has been treated with any investigational drugs within 30 days or 5 half lives whichever is longer, prior to the initiation of Screening.
Subject has any medical, psychiatric, addictive or other kind of disorder which compromises the ability of the subject to give written informed consent and/or to comply with procedures

Where it is running

City of Hope — Duarte, California, United States
Northwestern University — Chicago, Illinois, United States
University of Minnesota — Minneapolis, Minnesota, United States
M.D. Anderson Cancer Center — Houston, Texas, United States
Seattle Cancer Care Alliance — Seattle, Washington, United States

Full record on ClinicalTrials.gov

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