The Effect of Oxytocin on Fear Memory Consolidation Novel Intervention to Prevent Posttraumatic Stress Disorder (PTSD)

Completed · Not applicable · Has a placebo group

Conditions studied: Posttraumatic Stress Disorder

In brief

The purpose of the study is to learn how differences in learning under mildly-stressful circumstances may be changed by taking oxytocin. Oxytocin is a hormone made naturally in the body. The investigators will also examine the impact of any anxiety, depression, and stress related symptoms on learning processes.

Key facts

Study ID

NCT01466127

Run by

Massachusetts General Hospital

People needed

60

Starts

2011-10-01

Expected to finish

2014-05-01

Last updated by the study team

2017-04-14

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Men or women 18 to 65 years of age
• Score in study range on the Neuroticism-Extraversion-Openness-Five Factor Inventory (NEO-FFI)
• No current Axis I Diagnostic and Statistical Manual-IV (DSM) excluded diagnoses as determined by the Structured Clinical Interview DSM (SCID) completed within the past 4 months.
• Must be able and willing to understand study procedures and return to the clinic on two separate consecutive days for the fear-conditioning procedures.
• Subjects must be able to give informed consent and be willing and able to comply with study procedures.

You may not qualify if…

• Presence of a current DSM-IV Axis I diagnosis as measured by the SCID.
• A serious medical condition or other condition deemed likely to result in surgery or hospitalization, or which would make participation in the study difficult.
• Patients with a history of trauma resulting in head injury related seizures or with epilepsy (except a prior history of febrile seizures of infancy which are not exclusionary).
• Use of supplemental hormones (birth control, estrogen, testosterone, prednisone, etc) or narcotics.
• Pregnant or lactating women.
• Women of childbearing potential not using medically accepted forms of contraception.
• Current use of the excluded psychiatric medications.
• Known hypersensitivity to oxytocin
• Known hyponatremia.

Where it is running

• Center for Anxiety and Traumatic Disorders, MGH — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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