Vaginal Progesterone Versus Progesterone in Oil in Donor Egg Recipient In Vitro Fertilization Cycles Utilizing Vitrified Donor Eggs

Completed · Phase 4

Conditions studied: Infertility

In brief

The aim of this study is to evaluate both pharmaceutical therapy and advanced treatment techniques for infertile patients requiring in-vitro fertilization utilizing donor eggs.

Key facts

Study ID

NCT01465373

Run by

Fertility Centers of Illinois

People needed

10

Starts

2010-02-01

Expected to finish

2011-09-01

Last updated by the study team

2011-11-04

Who can join

Age: 21 and older, up to 49. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Oocyte Donors:
• Age 21-34 years of age
• BMI 18-34
• Normal ovarian reserve, defined as FSH <10 and AFC >10
• Medical evaluation consistent with FDA criteria for donor inclusion
• Donor Oocyte Recipients
• Documented history of infertility requiring donor oocyte for optimal fertility potential
• Documentation of a normal uterine cavity by hysteroscopy, hysterosonogram, or HSG within 1 year of study screening
• Fresh or Frozen Sperm

You may not qualify if…

• Oocyte Donors:
• Abnormal ovarian reserve, defined as FSH <10, AFC>10, prior poor response to controlled ovarian hyper-stimulation(COHS)
• Failure to meet FDA criteria for donor approval (risk factor and medical evaluation)
• Previous history of poor response to COHS
• Donor Oocyte Recipients:
• Uncontrolled hypothyroidism, hyperprolactinemia, or systemic disease that may interfere with study treatment
• Active thrombophlebitis or thromboembolic disorders, or a history of hormone associated thrombophlebitis or thromboembolic disorders
• Surgically aspirated sperm (TESE)
• 2 or more clinical pregnancy losses (excluding aneuploidy for previous autologous cycles)
• Clinically significant gynecologic pathology or uterine abnormality, such as submucosal fibroids > 5 cm, communicating hydrosalpinx, uncorrected uterine septum, undiagnosed vaginal bleeding, endometrial atypia, or any other condition that could adversely affect pregnancy outcomes
• History of 2 or more failed IVF donor cycles

Where it is running

• Fertility Centers of Illinois — Chicago, Illinois, United States

Full record on ClinicalTrials.gov

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