Minocycline in Patients With Alzheimer's Disease
Completed · Phase 2
Conditions studied: Mild Cognitive Impairment, Alzheimer's Disease
In brief
Cognitively normal individuals, patients with Mild Cognitive Impairment (MCI) or Alzheimer's Disease (AD) will undergo clinical screening, neuropsychological tests, blood and urine analyses, quantitative magnetic resonance imaging (MRI) and proton (1H ) and carbon 13 (13C) magnetic resonance spectroscopy (MRS). Each individual will receive minocycline oral administration for 4 weeks initially, after which MRI, MRS and neuropsychological results will be recorded. If no adverse side effects occur, subjects will continue minocycline administration for an additional 5 months.
Key facts
- Study ID
- NCT01463384
- Run by
- Huntington Medical Research Institutes
- People needed
- 13
- Starts
- 2011-09-01
- Expected to finish
- 2012-10-01
- Last updated by the study team
- 2014-09-25
Who can join
Age: 55 and older, up to 90. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Cognitively normal elderly subjects between the ages of 55-90 and patients aged 55 - 90 years who have mild cognitive impairment (MCI) or clinically defined Alzheimer's disease.
You may not qualify if…
- Any person with medical devices such as cardiac pacemakers/defibrillators or neuro-implants as they are contra-indications for MRI/MRS exam.
- Since the effects of MRI are unknown to the fetus or unborn child, any person who is or may be pregnant will be excluded from the study.
- History of known allergy or intolerance to minocycline or any other tetracycline
- Impaired renal function (plasma Creatinine) or blood urea nitrogen (BUN) levels exceeds twice normal upper limit which can result in higher serum levels of tetracycline, azotemia, hyperphosphatemia and acidosis.
Where it is running
- Huntington Medical Research Institutes — Pasadena, California, United States
Full record on ClinicalTrials.gov
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