Timing of Postpartum Depot Medroxyprogesterone Acetate Administration on Breastfeeding, Contraceptive Continuation, and Depression

Completed · Phase 4

Conditions studied: Contraception, Postpartum Depression, Lactation

In brief

The investigators plan to enroll 184 women who are planning to breastfeed and use DMPA after delivery to find out whether the timing of postpartum administration of DMPA (prior to hospital discharge or 4-6 weeks after delivery) affects the duration or exclusivity of breastfeeding among women who plan to breastfeed their infants.

Key facts

Study ID

NCT01463202

Run by

Beatrice Chen

People needed

184

Starts

2011-11-01

Expected to finish

2017-10-16

Last updated by the study team

2018-08-31

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Age > 18 years old and > 24 0/7 weeks pregnant at time of enrollment
• Planning to deliver at Magee-Womens Hospital and to breastfeed
• Plans to use DMPA for postpartum contraception for at least 6 months
• Willing and able to provide informed consent in English and to comply with study protocol

You may not qualify if…

• Intolerance of irregular vaginal bleeding
• Severe coagulation disorder
• Severe liver disease (LFTs >2x upper limits of normal at time of randomization)
• Contraindications to breastfeeding: maternal HIV infection; active herpes simplex with breast lesions; active varicella; active, untreated tuberculosis; antineoplastic, thyrotoxic, or immunosuppressive medications; concern that the infant may have galactosemia
• History of breast cancer, reduction or augmentation surgery
• History of severe clinical depression
• Multiple gestation

Where it is running

• Center for Family Planning Research, Magee-Womens Hospital — Pittsburgh, Pennsylvania, United States

Full record on ClinicalTrials.gov

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