Retapamulin for Reducing MRSA Nasal Carriage

Completed · Phase 4 · Has a placebo group

Conditions studied: Methicillin-Resistant Staphylococcus Aureus

In brief

The investigators will conduct a randomized placebo-controlled double-blinded study of nasal decolonization with retapamulin vs. placebo for the eradication of MRSA nasal carriage among adult carriers with low-level (MIC 8-256) and high-level mupirocin resistant (MIC \>256) strains. Objectives: 1. To determine the percent of intervention vs. control patients with successful MRSA nasal decolonization as determined by bilateral nares swabs following a 5-day twice-a-day regimen of retapamulin. 2. To determine the time to decolonization based upon interim and final bilateral nares swabs. 3. To determine the acceptability of retapamulin by surveying participants about their experience and adverse events experienced during this study. The duration of participant follow-up is expected to last up to 7 weeks. This study will evaluate the safety and effectiveness of Altabax (retapamulin) during decolonization of MRSA carriers with mupirocin-resistant strains, stratified by low-level and high-level resistance to mupirocin. Mupirocin resistance is increasingly common and there is no approved substitute topical agent for decolonization of the MRSA nasal reservoir.

Key facts

Study ID

NCT01461668

Run by

University of California, Irvine

People needed

53

Starts

2012-07-01

Expected to finish

2017-12-01

Last updated by the study team

2018-04-02

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 18 years of age or older
• Have a type of MRSA that is resistant to mupirocin (a drug used to treat MRSA)

You may not qualify if…

• Allergic to retapamulin
• Unable to use retapamulin via your nose (i.e. nose surgery, etc.)
• Are pregnant and/or breastfeeding

Where it is running

• University of California, Irivne — Irvine, California, United States

Full record on ClinicalTrials.gov

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