Pediatric Philadelphia Positive Acute Lymphoblastic Leukemia

Completed · Phase 2

Conditions studied: Leukemia, Pediatric

In brief

The purpose of this study is to determine whether Dasatinib when added to standard chemotherapy is effective and safe in the treatment of pediatric philadelphia chromosome positive acute lymphoblastic leukemia

Key facts

Study ID

NCT01460160

Run by

Bristol-Myers Squibb

People needed

106

Starts

2012-04-13

Expected to finish

2021-06-01

Last updated by the study team

2021-12-08

Who can join

Age: 1 and older, up to 17. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Newly diagnosed Philadelphia chromosome positive Acute Lymphoblastic Leukemia (ALL)
• Age >1 year and < less than 18 years old
• Induction chemotherapy ≤ 14 days according to institutional standard of care
• Adequate liver, renal and cardiac function

You may not qualify if…

• Prior treatment with a Oncogene fusion protein (BCR-ABL) inhibitor
• Extramedullary involvement of the testicles
• Active systemic bacterial, fungal or viral infection
• Down syndrome

Where it is running

• Phoenix Children'S Hospital/Ctr. For Cancer & Blood Ctr. — Phoenix, Arizona, United States
• University Of Arkansas For Medical Sciences — Little Rock, Arkansas, United States
• Antranik Agop Bedros — Loma Linda, California, United States
• Miller Children's and Women Hospital — Long Beach, California, United States
• Children'S Hospital Of L.A. — Los Angeles, California, United States
• Southern California Permanente Medical Group — Los Angeles, California, United States
• Valley Children's Hospital — Madera, California, United States
• Children's Hospital of Orange County — Orange, California, United States
• Lpch & Sumc — Palo Alto, California, United States
• Kaiser Medical Center — Roseville, California, United States
• Ucsf - Hematology/Oncology — San Francisco, California, United States
• Children'S Hospital Colorado — Aurora, Colorado, United States
• Connecticut Children's Medical Center — Hartford, Connecticut, United States
• A. I. Dupont Hospital For Children — Wilmington, Delaware, United States
• Children'S National Medical Center — Washington D.C., District of Columbia, United States
• Lee Memorial Health System — Fort Myers, Florida, United States
• University Of Florida — Gainesville, Florida, United States
• Nemours Children'S Clinic — Jacksonville, Florida, United States
• Md Anderson Cancer Center Orlando — Orlando, Florida, United States
• Nemours Childrens Hospital — Orlando, Florida, United States
• All Children'S Hospital — St. Petersburg, Florida, United States
• St. Joseph's Children's Hospital — Tampa, Florida, United States
• St. Mary'S — West Palm Beach, Florida, United States
• Children's Healthcare Of Atlanta — Atlanta, Georgia, United States
• University Of Alabama At Birmingham — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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