This Study is to Determine if Degenerative Spinal Pain and Disorders Cause the Levels of Substance P to Change in a Patients Saliva, Blood and/or Cerebrospinal Fluid.
Stopped early
Conditions studied: Spinal Disease, Spinal Radiculopathy, Myelopathy, Neurogenic Claudication
In brief
The objective of this pilot study is to determine if degenerative spinal disorders such as acute radiculopathy, myelopathy, stenosis, or disc and facet disease cause detectable alterations in Substance P levels in saliva, serum and cerebrospinal fluid. If this pilot study shows a correlation between Substance P levels and pain associated with degenerative spinal disorders, then a larger study will be initiated to determine the feasibility of using Substance P levels in the diagnosis and treatment of degenerative spinal disease.
Key facts
- Study ID
- NCT01458938
- Run by
- Carolina Neurosurgery & Spine Associates
- People needed
- 53
- Starts
- 2009-07-01
- Expected to finish
- 2014-04-01
- Last updated by the study team
- 2017-02-01
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Undergoing spinal surgery for medically refractory spinal radiculopathy,
- myelopathy or neurogenic claudication based on either history, physical examination or radiologic studies demonstrating neural compression or degenerative disc disease.
- Undergoing surgery for medically refractory axial spinal pain.
You may not qualify if…
- Previous spinal procedures or operations,
- radicular pain,
- history of fibromyalgia,
- chronic pain,
- rheumatoid arthritis,
- autoimmune disorders,
- HIV,
- PTSD,
- Major Depressive Disorder,
- migraine headaches or active rhinosinusitis,
- nicotine intake
Where it is running
- Carolina Neurosurgery and Spine Associates, P.A. — Charlotte, North Carolina, United States
Full record on ClinicalTrials.gov
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