The Effect of Natalizumab (Tysabri) on Sexual Dysfunction in Multiple Sclerosis

Completed · Not applicable

Conditions studied: Multiple Sclerosis

In brief

The purpose of this study is to determine if sexual dysfunction symptoms and quality of life measures in patients with Multiple Sclerosis may be improved in patients that are prescribed Tysabri.

Key facts

Study ID

NCT01455220

Run by

University of South Florida

People needed

45

Starts

2011-01-01

Expected to finish

2014-10-01

Last updated by the study team

2017-03-31

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Must give written informed consent and provide all authorizations required by local law(ex. Protected Health Information, PHI)
• Minimum baseline score of 15 for the primary sexual dysfunction subscale of the MSISQ-19 (questions 12,16,17,18,19)
• Men and Women between 18 and 60 years of age
• Must have EDSS less than or equal to 5.5 at baseline
• Must be able to walk at least 100m without assistive devices
• Must have a documented diagnosis of a relapsing remitting form of MS as defined by the revised McDonald Committee criteria (Polman et al.,2005)
• Must have a recent MRI (within 1 year from baseline)
• Must satisfy the locally approved therapeutic indications for TYSABRI
• Must be stable in disability for at least 30 days prior to enrollment to the study
• Must be Natalizumab naïve
• Must be stable in symptomatic management of the disease, for at least 30 days prior to enrollment in the study
• Must be on a stable regimen of all symptomatic medications for Multiple Sclerosis especially those that could interfere with sexual function (specifically anti-cholinergics, anti-hypertensives, etc.) for at least 30 days prior to the enrollment.
• Must be considered by the Investigator to be free of signs and symptoms suggestive of PML based on medical history, physical examination, or laboratory testing.
• Must be willing to discontinue and remain free from concomitant immunosuppressive or immunomodulatory treatment (including IFN and GA) while being treated with Natalizumab during the study

You may not qualify if…

• Must give written informed consent and provide all authorizations required by local law(ex. Protected Health Information, PHI)
• Minimum baseline score of 15 for the primary sexual dysfunction subscale of the MSISQ-19 (questions 12,16,17,18,19)
• Men and Women between 18 and 60 years of age
• Must have EDSS less than or equal to 5.5 at baseline
• Must be able to walk at least 100m without assistive devices
• Must have a documented diagnosis of a relapsing remitting form of MS as defined by the revised McDonald Committee criteria (Polman et al.,2005)
• Must have a recent MRI (within 1 year from baseline)
• Must satisfy the locally approved therapeutic indications for TYSABRI
• Must be stable in disability for at least 30 days prior to enrollment to the study
• Must be Natalizumab naïve
• Must be stable in symptomatic management of the disease, for at least 30 days prior to enrollment in the study
• Must be on a stable regimen of all symptomatic medications for Multiple Sclerosis especially those that could interfere with sexual function (specifically anti-cholinergics, anti-hypertensives, etc.) for at least 30 days prior to the enrollment.
• Must be considered by the Investigator to be free of signs and symptoms suggestive of PML based on medical history, physical examination, or laboratory testing.
• Must be willing to discontinue and remain free from concomitant immunosuppressive or immunomodulatory treatment (including IFN and GA) while being treated with Natalizumab during the study

Where it is running

• University of South Florida, Frank and Carol Morsani Center — Tampa, Florida, United States

Full record on ClinicalTrials.gov

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