Cognitive-Behavioral Therapy (CBT) in Women Discontinuing Antidepressant for Pregnancy
Completed · Not applicable
Conditions studied: Depression, Postpartum Depression, Antenatal Depression
In brief
The overarching goal of this study is to adapt a cognitive behavioral prevention of recurrence treatment (CBT-PR) for women with a history of recurrent major depressive disorder who decide to discontinue their maintenance anti-depressant (AD) treatment for pregnancy.
Key facts
- Study ID
- NCT01453114
- Run by
- Massachusetts General Hospital
- People needed
- 15
- Starts
- 2008-11-01
- Expected to finish
- 2012-07-01
- Last updated by the study team
- 2015-04-07
Who can join
Age: 18 and older. Sex: female. Healthy volunteers: accepted.
You may qualify if…
- Subjects will include women 18 years and older who are either planning pregnancy or already pregnant and meet the following criteria:
- Currently meet criteria for stable remission from depression (defined as a baseline score of ≤ 9 on the Hamilton Rating Scale for Depression (HRSD) and documented clinical remission for a minimum of six months prior to randomization)
- Current or recent treatment with an antidepressant (stable dosage for at least the last four weeks)
- Have a history of a major depressive episode
- Decide to discontinue antidepressant medication for pregnancy
- Currently receive ongoing psychiatric care provided by a physician outside the MGH Center for Women's Mental Health, and written, informed consent.
You may not qualify if…
- Significant risk for self-harm or harm to others
- Psychotic symptoms
- Meeting criteria for a primary SCID-I/P diagnosis of schizophrenia, bipolar disorder, an active eating disorder, dementia, delirium, or other cognitive disorder
- Presence of an active substance and/or alcohol abuse disorder within six months prior to screening visit
- Current use of mood stabilizers, antipsychotics or antiepileptics
- Have received cognitive-behavioral or interpersonal therapy within the last year
- Diagnosed with a medical disorder that has a known association with depressive symptoms (e. g. thyroid disorder).
Where it is running
- Massachusetts General Hospital — Boston, Massachusetts, United States
Full record on ClinicalTrials.gov
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