A Grapefruit Feeding Trial in Healthy, Overweight Adults

Completed · Not applicable

Conditions studied: Weight Loss, Obesity, Cardiovascular Risk Factors

In brief

Folklore has suggested that consuming grapefruit may promote weight control. Sparse data exist to support this hypothesis, though there is some evidence of health promotional effects regarding blood pressure and lipid profiles. The aims of this randomized controlled trial are to determine the role of grapefruit in: 1. Reducing weight 2. Reducing blood pressure 3. Reducing inflammation 4. Improving the lipid profile. The investigators hypothesize that six weeks of daily consumption of grapefruit will reduce weight, blood pressure, and inflammation while improving the lipid profile in overweight, healthy adults.

Key facts

Study ID

NCT01452841

Run by

University of Arizona

People needed

85

Starts

2009-08-01

Expected to finish

2011-04-01

Last updated by the study team

2011-10-17

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Adults, men and premenopausal women
• BMI: 25-45 kg/m2
• Willing to maintain current exercise regimen (not to exceed 10 hours/week)
• Willing to follow a diet low in bioactive rich fruits and vegetables and with no citrus

You may not qualify if…

• History of chronic disease
• Metabolic disease
• Inflammatory disease
• High cholesterol (>225 mg/dL)
• Smoker
• Taking medications metabolized by the Cytochrome P450 3A enzyme
• History of alcohol or drug abuse

Where it is running

• University of Arizona — Tucson, Arizona, United States

Full record on ClinicalTrials.gov

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