Relationship Between Systemic Fatty Acid Availability and Insulin Sensitivity

Completed

Conditions studied: Obesity

In brief

The investigators specific aim is to compare the relationship between systemic fatty acid availability and insulin sensitivity in a relatively homogenous population of obese adults. The investigators anticipate 1) greater systemic fatty acid availability will be associated with lower insulin sensitivity and 2) greater systemic fatty acid availability will be associated with greater accumulation of fatty acid intermediates and pro-inflammatory markers.

Key facts

Study ID

NCT01452048

Run by

University of Michigan

People needed

38

Starts

2011-09-01

Expected to finish

2016-05-26

Last updated by the study team

2022-03-21

Who can join

Age: 18 and older, up to 45. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Body mass index [BMI]: 35-45 kg/m2; All women must be pre-menopausal; Non-exerciser (no regularly planned exercise/physical activity)

You may not qualify if…

• Weight instability ≥ ±5 lbs. in past month; medications known to affect lipid and/or glucose metabolism; Pregnancy or actively breast feeding

Where it is running

• Michigan Clincal Research Unit — Ann Arbor, Michigan, United States

Full record on ClinicalTrials.gov

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