Exercise Dose Response for Improving Insulin Sensitivity
Completed · Not applicable
Conditions studied: Obesity
In brief
Many of the beneficial metabolic effects of endurance exercise training are not due to adaptations to weeks, months, or even years of training, but rather much is due to the response to the most recent exercise session(s). Therefore, the investigators contend that lifestyle interventions for obese individuals should be tailored to optimize the metabolic effects of the most recent exercise session(s). But the "dose" of exercise necessary to evoke these beneficial responses is not known, and the mechanisms responsible for these improvements are poorly understood. The findings from these studies will: 1) establish the minimum "dose" of a single exercise session necessary to improve insulin sensitivity the next day in obese adults, 2) characterize the underlying metabolic factors responsible for the improvement in insulin sensitivity, and 3) assess the cumulative metabolic adaptations that occur over days, weeks, and months of a low-intensity/low-volume lifestyle exercise program. Findings from these studies will provide valuable information for the development of lifestyle programs aimed at maximizing the key metabolic health benefits of each exercise session in obese patients.
Key facts
- Study ID
- NCT01452035
- Run by
- University of Michigan
- People needed
- 13
- Starts
- 2009-01-01
- Expected to finish
- 2015-12-01
- Last updated by the study team
- 2016-11-08
Who can join
Age: 18 and older, up to 45. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Body Mass Index [BMI] = 30-45 kg/m2, weight stable (± 5 lbs in the past month), fasting blood glucose concentration must be <125 mg/dl.
You may not qualify if…
- pregnancy, evidence of cardiovascular or metabolic disease, taking medications know to influence metabolism.
Where it is running
- Michigan Clincal Research Unit — Ann Arbor, Michigan, United States
Full record on ClinicalTrials.gov
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