Oral Risperidone Versus Injectable Paliperidone Palmitate for Treating First-Episode Schizophrenia
Completed · Phase 4
Conditions studied: Schizophrenia (Recent-onset)
In brief
This study will determine the efficacy of oral risperidone (Risperdal) versus long-acting injectable paliperidone palmitate (Invega Sustenna) in treating people with first-episode schizophrenia.
Key facts
- Study ID
- NCT01451736
- Run by
- University of California, Los Angeles
- People needed
- 146
- Starts
- 2011-10-01
- Expected to finish
- 2021-12-31
- Last updated by the study team
- 2022-04-11
Who can join
Age: 18 and older, up to 45. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- A first episode of a psychotic illness is occurring or did occur within the last 2 years;
- A diagnosis by Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition(DSM-IV)of schizophrenia, schizoaffective disorder, depressed type, or schizophreniform disorder; and
- Between 18 and 45 years of age.
You may not qualify if…
- Neurological disorder (e.g., epilepsy) or significant head injury;
- Significant alcohol or substance use disorder within the six months prior to the first episode and evidence that substance abuse triggered the psychotic episode or makes the schizophrenia diagnosis ambiguous;
- Mental retardation, i.e. premorbid intelligence quotient (IQ) less than 70;
- Insufficient acculturation and fluency in the English language to avoid invalidating research measures of thought, language, and speech disorder or of verbal abilities;
- Residence likely to be outside of commuting distance of the University of California, Los Angeles (UCLA) Aftercare Research Program; or
- Patient has shown an inadequate response to an adequate previous trial of oral or long-acting injectable risperidone, paliperidone, or paliperidone palmitate.
Where it is running
- UCLA Semel Institute for Neuroscience and Human Behavior — Los Angeles, California, United States
Full record on ClinicalTrials.gov
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