Early Detection of Pulmonary Arterial Hypertension Using Cardiac Magnetic Resonance Imaging
Completed
Conditions studied: Pulmonary Hypertension, Pulmonary Arterial Hypertension
In brief
Cardiac magnetic resonance imaging has emerged as a potential valuable test for the early detection of Pulmonary Arterial Hypertension. A number of reports have provided some preliminary evidence that Pulmonary Artery (PA) stiffness may be accurately detected by imaging of the pulmonary artery in order to measure PA stiffness. In addition, cardiac MRI could play provide early and effective treatment for Pulmonary Arterial Hypertension (PAH).
Key facts
- Study ID
- NCT01451255
- Run by
- Mayo Clinic
- People needed
- 90
- Starts
- 2011-08-01
- Expected to finish
- 2014-06-01
- Last updated by the study team
- 2016-03-17
Who can join
Age: 18 and older, up to 99. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Consecutive patients aged ≥ 18 years with PAH as dictated by a comprehensive examination and echocardiography will be included for enrollment.
You may not qualify if…
- Age < 18 years
- Pregnancy
- Mechanical ventilation
- Acute or chronic renal failure (creatinine clearance < 30 ml/min or requiring renal replacement therapy)
- Inability to perform MRI (i.e. claustrophobia, severe obesity (> 150 kg), device incompatible with MRI)
- Significant arrhythmia that precludes adequate ECG-gating for the MRI (i.e. atrial fibrillation with highly variable cycle lengths)
- Prior heart or lung transplantation
- Left ventricular systolic (ejection fraction < 50%) or diastolic failure (based on Framingham criteria for heart failure with preserved ejection fraction)
- Significant left-sided valvular disease (≥ moderate aortic stenosis, mitral stenosis, aortic regurgitation, mitral regurgitation) or prior valve surgery
Where it is running
- Mayo Clinic in Florida — Jacksonville, Florida, United States
- Mayo Clinic — Jacksonville, Florida, United States
Full record on ClinicalTrials.gov
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