Strength Training Induced Alterations in Markers of Immune Function
Completed · Not applicable
Conditions studied: Inflammation
In brief
Exercise has been used to help prevent or slow the progression of inflammation-related disease; however, the mechanism by which this activity may lower concentrations of inflammatory markers remains unclear. The melanocortin receptors 1,3 and 5 (MC1R, MC3R and MC5R) have been shown to function in an anti-inflammatory manner and have the potential to mediate the positive immune adaptations associated with regular physical activity. Preliminary data suggest that MC3R gene expression increases in whole blood after chronic exercise training. The primary aim of the current study is to explore whether this change in gene expression translates into alterations in MC1R, MC3R, or MC5R monocyte surface expression. The secondary aim is to examine the relationship between surface expression of these receptors and circulating inflammatory profiles. The investigators will recruit 42 untrained, healthy males and females aged 18-35 yrs. Half of the group will be placed on an exercise program for 15 weeks. The other half will serve as untrained control subjects. In addition to basic anthropometric measures, the investigators will measure concentrations of inflammatory and anti-inflammatory cytokines (ELISA) and cell surface expression of MC1R, MC3R, and MC5R on monocytes (flow cytometry).
Key facts
- Study ID
- NCT01450852
- Run by
- Louisiana State University Health Sciences Center in New Orleans
- People needed
- 42
- Starts
- 2010-01-01
- Expected to finish
- 2010-05-01
- Last updated by the study team
- 2011-10-12
Who can join
Age: 18 and older, up to 30. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- All Participants Must be Healthy
- The Strength Training Group Members Must Be Approved For Participation by a Licensed MD
You may not qualify if…
- Females may not be pregnant
- Unhealthy participants (those with existing conditions)
Where it is running
- Louisiana State University — Baton Rouge, Louisiana, United States
Full record on ClinicalTrials.gov
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