Peers for Promoting Adolescent Transplant Health

Completed · Not applicable

Conditions studied: Behavior and Behavior Mechanisms

In brief

Adolescents with solid organ transplants have poorer outcomes than adults, and do not respond as well to post-rejection treatment. In addition to well-recognized declines in individual health-related quality of life, premature graft loss creates considerable health and economic burdens. High nonadherence rates among adolescents are believed to contribute majorly to rejection, premature allograft dysfunction and failure. Studies suggest that a telephone-based peer mentoring approach, with texting and e-communication, is a promising, practical means to promote medication adherence in adolescent solid organ transplant recipients. The study's main objectives are 1) to determine the efficacy of peer mentoring to improve medication adherence and health-related quality of life vs. usual care in adolescents and young adults with solid organ transplants, and 2) to determine the mechanisms through which peer mentoring impacts medication adherence and health-related quality of life.

Key facts

Study ID

NCT01450033

Run by

Children's Hospital of Philadelphia

People needed

74

Starts

2011-09-01

Expected to finish

2017-03-29

Last updated by the study team

2018-05-16

Who can join

Age: 14 and older, up to 23. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Males or females age 14 to 23 years
• Greater than one year post kidney, heart or liver transplant
• Able to speak and read in English
• Willing and able to provide informed consent or assent
• Parental guardian permission (informed consent) if appropriate

You may not qualify if…

• Unwilling to participate
• Unable to speak or read in English
• Unable to provide informed assent or consent
• Estimated glomerular filtration rate (eGFR) less than 20 ml/min/1.73m\^2
• On dialysis
• Less than three months post transplant
• Post-transplant lymphoproliferative disease

Where it is running

• The Children's Hospital of Philadelphia — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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