Rapamycin as a Means of Interference With Reconsolidation of Posttraumatic Stress Disorder-related Traumatic Memory

Completed · Not applicable · Has a placebo group

Conditions studied: Posttraumatic Stress Disorder

In brief

The purpose of the proposed study is to determine if pairing reactivation of a traumatic memory with a single administration of Rapamycin (e.g., Sirolimus) in men with combat-related Posttraumatic Stress Disorder leads to a reduction of the emotional strength of that particular traumatic memory. The following hypotheses will be tested: 1. Traumatic memory reactivation paired with a single dose of Rapamycin will decrease objective measures of stress and self-report of stress during replay of the traumatic memory, relative to, subjects receiving placebo. 2. Pairing administration of Rapamycin with traumatic memory reactivation will decrease symptoms of Posttraumatic Stress Disorder one month and three months later, relative to patients receiving placebo.

Key facts

Study ID

NCT01449955

Run by

University of Texas Southwestern Medical Center

People needed

54

Starts

2008-08-01

Expected to finish

2010-07-01

Last updated by the study team

2018-07-18

Who can join

Age: 18 and older. Sex: male. Healthy volunteers: not accepted.

You may qualify if…

• Male Veterans
• Diagnosis of Posttraumatic Stress Disorder related to combat

You may not qualify if…

• Hypersensitivity to Rapamycin
• Organic brain damage (including unresolved Traumatic Brain Injury sequela)
• Substance dependence in the last three months
• On any immunosuppressant therapy
• Prominent suicidal or homicidal features
• Medical conditions: systemic infections, congestive heart failure, renal failure, hepatic failure

Where it is running

• VA North Texas Healthcare System — Dallas, Texas, United States

Full record on ClinicalTrials.gov

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