Preemptive Resuscitation for Eradication of Septic Shock

Completed · Not applicable

Conditions studied: Sepsis, Severe Sepsis

In brief

The purpose of this study is to assess the ability of an empiric resuscitation strategy compared to standard care to decrease the incidence of organ failure in normotensive sepsis patients.

Key facts

Study ID

NCT01449721

Run by

Christiana Care Health Services

People needed

142

Starts

2011-09-01

Expected to finish

2016-01-01

Last updated by the study team

2017-10-04

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Emergency department patient with suspected or confirmed infection as primary reason for admission
• Serum venous lactate 2.0 - 3.9 mmol/L
• Hospital admission planned

You may not qualify if…

• Age < 18 years
• Pregnancy
• Serum lactate ≥ 4.0 mmol/L
• Any vasopressor or inotrope requirement
• Mechanical ventilation or non-invasive positive pressure ventilation
• Chronic end-stage renal disease requiring hemodialysis
• Pulmonary edema as diagnosed by the primary care team
• Requirement for surgery within the treatment protocol timeframe
• Inability to obtain informed consent from subject or surrogate
• Patient to receive comfort measures only

Where it is running

• Christiana Care Health System — Newark, Delaware, United States
• Beth Israel Deaconess Medical Center — Boston, Massachusetts, United States
• Detroit Receiving Hospital/University Health Center — Detroit, Michigan, United States
• University of Mississippi Medical Center — Jackson, Mississippi, United States
• Cooper University Hospital:Cooper Medical School of Rowan University — Camden, New Jersey, United States

Full record on ClinicalTrials.gov

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