Vest Prevention of Early Sudden Death Trial and VEST Registry

Completed · Not applicable

Conditions studied: Myocardial Infarction, Ventricular Dysfunction, Sudden Death, Ventricular Tachycardia, Ventricular Fibrillation

In brief

This study explores the hypothesis that wearable defibrillators can impact mortality by reducing sudden death during the first three months after a heart attack in persons with high risk for life-threatening arrhythmias.

Key facts

Study ID

NCT01446965

Run by

University of California, San Francisco

People needed

2348

Starts

2008-07-01

Expected to finish

2019-05-31

Last updated by the study team

2021-01-20

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients identified in the hospital or within 7 days after discharge with a diagnosis of an acute MI (STEMI or Non-STEMI)
• LV ejection fraction ≤35% determined at the following time point:
• If no PCI within the first 8 hours following the MI: ≥ 8 hours after MI
• If acute PCI occurs within 8 hours of MI: ≥8 hours after PCI
• If CABG is planned (before or within 7 days of discharge), wait to enroll and then use the most recent assessment at least 48 hours post CABG
• Age ≥ 18 years

You may not qualify if…

• Existing ICD or indication for an ICD at the time of screening
• Existing unipolar pacemakers/leads
• Chronic renal failure requiring hemodialysis after hospital discharge
• Chest circumference too small or too large for LifeVest garment*
• Participants discharged to an institutional setting with an anticipated stay > 7 days
• Pregnancy
• Inability to consent
• Any other condition or circumstance that in the judgment of the clinician makes the participant unsuitable for the study.

Where it is running

• Cardiovascular Consultants Heart Center — Fresno, California, United States
• Salinas Valley Memorial Healthcare System — Salinas, California, United States
• University of California, San Francisco — San Francisco, California, United States
• University of Colorado — Aurora, Colorado, United States
• Hartford Hospital — Hartford, Connecticut, United States
• Christiana Care Health Services — Newark, Delaware, United States
• University of Florida — Gainesville, Florida, United States
• Watson Clinic for Research, Inc. — Lakeland, Florida, United States
• Melbourne Cardiac Resarch Institute — Melbourne, Florida, United States
• Florida Heart Group/Florida Hospital — Orlando, Florida, United States
• Advocate Christ Hospital — Oak Lawn, Illinois, United States
• Lutheran General — Park Ridge, Illinois, United States
• The Heart Group/Deaconess Hospital — Evansville, Indiana, United States
• Indiana University — Indianapolis, Indiana, United States
• St. Vincent Medical Group — Indianapolis, Indiana, United States
• Western Kentucky Heart and Lung — Bowling Green, Kentucky, United States
• University of Kentucky Gill Heart Institute — Lexington, Kentucky, United States
• Ochsner Clinic — New Orleans, Louisiana, United States
• Tufts Medical Center — Boston, Massachusetts, United States
• Massachusetts General Hospital — Boston, Massachusetts, United States
• Brigham and Women's Hospital — Boston, Massachusetts, United States
• University of Massachusetts Memorial — Worcester, Massachusetts, United States
• The Valley Hospital — Ridgewood, New Jersey, United States
• Presbyterian Heart Group — Albuquerque, New Mexico, United States
• Alaska Heart Institute — Anchorage, Alaska, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.