Sleep Apnea in TIA/Stroke: Reducing Cardiovascular Risk With Positive Airway Pressure

Completed · Not applicable

Conditions studied: Transient Ischemic Attack, Stroke

In brief

The goal of this study is to develop a novel study design to safely and ethically conduct a long-term randomized controlled trial among patients at high risk for both sleep apnea and cardiovascular events that will examine whether effective positive airway pressure(PAP) therapy reduces cardiovascular risk. Patients with transient ischemic attack(TIA) or stroke have a high prevalence of sleep apnea(60-80%), and they are at high risk of cardiovascular events(myocardial infarction, congestive heart failure, recurrent stroke, and cardiovascular death)in the first year post event, despite current prevent strategies. Therefore, the treatment of sleep apnea may represent a novel therapeutic target to reduce cardiovascular outcomes in this high risk population.

Key facts

Study ID

NCT01446913

Run by

Yale University

People needed

255

Starts

2011-05-01

Expected to finish

2014-04-01

Last updated by the study team

2020-11-18

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 18 years and older
• TIA or ischemic stroke
• within 1 week of neurological symptom onset
• brain imaging within 24 hours

You may not qualify if…

• known to have sleep apnea
• suspected sleep disorder other than sleep apnea
• hospice patients or patients receiving comfort only measures
• patients unable to use a nasal or face mask
• patients who require mechanical ventilation
• Non English language patients
• inability to provide informed consent
• active suicidal ideation
• live outside the recruitment area
• provider does not allow researcher to contact patient

Where it is running

• Yale University — New Haven, Connecticut, United States
• University of Indiana — Indianapolis, Indiana, United States

Full record on ClinicalTrials.gov

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