Diagnostic Study of Rapid Regadenoson Stress Cardiovascular Magnetic Resonance (CMR) to Detect Coronary Artery Disease

Status unconfirmed · Phase 4

Conditions studied: Coronary Artery Disease

In brief

This study is designed to evaluate the feasibility and diagnostic performance of a novel rapid regadenoson stress CMR protocol for detecting of obstructive coronary artery disease.

Key facts

Study ID

NCT01446094

Run by

Dipan Shah

People needed

50

Starts

2011-08-01

Expected to finish

2018-06-01

Last updated by the study team

2017-10-03

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Aged 18 years or older
• Scheduled for invasive coronary angiography

You may not qualify if…

• Inability to give informed consent
• Possible pregnancy (confirmed by urine test)
• Women who are breastfeeding
• Severe claustrophobia
• Inability to lie flat for 20-30 minutes (the anticipated amount of time to complete the MRI procedure)
• Individuals with cochlear implants
• Individuals with non-MRI compatible aneurysm clips
• Potential contraindications to regadenoson use due to:
• Severe lung disease (active wheezing) Severe bradycardia (heart rate < 40 beats/min) Second- or third-degree atrioventricular heart block Sick sinus syndrome History of Long QT syndrome Severe hypotension (systolic BP < 80 mm Hg) Decompensated heart failure
• Contraindication to administration of Gadolinium (Gd) based contrast agents (GBCA):
• Stage 4 or 5 chronic kidney disease (eGFR < 30 ml/min/1.73 m2) Known allergy to GBCA
• Special Considerations:
• Although individuals who have an occupational history of welding, grinding, or other metal work will not be excluded from the study, they must undergo an orbital x-ray, to exclude any occult metal fragments, before they can participate in this study.

Where it is running

• The Methodist Hospital — Houston, Texas, United States (enrolling)

Full record on ClinicalTrials.gov

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