Comparing the Reliability of Expressed Prostatic Secretion (EPS) and Post Massage Urine (PMU) for the Prediction of Prostate Cancer Biopsy Outcome

Running, not enrolling · Not applicable

Conditions studied: Conditions Influencing Health Status, Healthy, Prostate Cancer

In brief

This randomized pilot phase I trial studies the best way, either expressed prostatic secretion (EPS) or post massage urine (PMU) biomarkers, of predicting biopsy results in patients undergoing prostate biopsy. Studying samples of urine in the laboratory may help doctors detect prostate cancer. It is not yet known whether EPS or PMU biomarkers are more effective in predicting prostate biopsy results

Key facts

Study ID: NCT01441687
Run by: City of Hope Medical Center
People needed: 243
Starts: 2009-07-14
Expected to finish: 2027-02-03
Last updated by the study team: 2026-03-23

Who can join

Age: 18 and older. Sex: male. Healthy volunteers: accepted.

You may qualify if…

All men who will be undergoing transrectal ultrasound of the prostate (TRUSP) with biopsy in the department of Urology or participating urology clinics for the evaluation of prostate cancer

You may not qualify if…

Men with a previous diagnosis of prostate cancer
Men without a prior diagnosis of prostate cancer but who have previously undergone a biopsy for a suspicious DRE or PSA
Men with a prior diagnosis of cancer < 5 years ago, excluding basal cell carcinoma and/or squamous cell carcinoma

Where it is running

Chinn & Chinn Urology Associates, Inc. — Arcadia, California, United States
City of Hope Medical Center — Duarte, California, United States
Citrus Valley Urologic Medical Group — Glendora, California, United States
Dr. Felix Chi-Ming Yip — Monterey Park, California, United States
City of Hope- South Pasadena Cancer Center — South Pasadena, California, United States

Full record on ClinicalTrials.gov

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