Efficacy of Gabapentin in Prevention of Tourniquet Pain and Hypertension

Withdrawn before enrolling · Early Phase 1 · Has a placebo group

Conditions studied: Tourniquet-induced Pain, Tourniquet-induced Hypertension

In brief

The purpose of the study is to find out if taking a dose of gabapentin 600 mg by mouth (po) before surgery will help prevent the development of tourniquet pain and hypertension while the tourniquet is inflated during orif of tibia fracture.

Key facts

Study ID

NCT01441531

Run by

Baylor College of Medicine

People needed

0

Starts

2012-01-01

Expected to finish

2014-06-01

Last updated by the study team

2015-03-17

Who can join

Age: 18 and older, up to 64. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patient ages 18-64
• ASA physical status 1-3
• Schedule for orif tibia fracture with use of pneumatic tourniquet

You may not qualify if…

• Allergy to study medications
• polytrauma
• lower extremity crush injury
• chronic opioid use
• sickle cell disease or trait
• peripheral vascular disease
• poorly controlled hypertension
• history of DVT/PE
• morbid obesity (BMI > 35)
• patient or surgeon refusal
• patient inability to properly describe postoperative pain to investigators

Where it is running

• Ben Taub General Hospital — Houston, Texas, United States

Full record on ClinicalTrials.gov

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