Endothelial Function, Arterial Stiffness and Components

Completed

Conditions studied: Acute Lymphoblastic Leukemia

In brief

Specific Aim: Compare the endothelial function, arterial stiffness and components of metabolic syndrome of childhood Acute Lymphoblastic Leukemia (ALL) survivors to healthy sibling controls. Plan: A cross sectional study comparing ALL survivors to sibling controls including measures of endothelial function and arterial stiffness obtained form a peripheral artery tonometry device, height, weight, waist circumference, fasting lipid, glucose and insulin.

Key facts

Study ID

NCT01439217

Run by

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

People needed

32

Starts

2011-06-01

Expected to finish

2013-02-01

Last updated by the study team

2013-04-17

Who can join

Age: 8 and older, up to 28. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Survivor:
• Inclusion
• Ages 8-28 (8 is chosen as lower age limit because developmental understanding will allow survivor to follow instructions for procedures, 28 is chosen as upper limit to include age ranges seen for treatment in the pediatric program)
• Off therapy for at least 6 months and not more than 10 years (6 months
• Inclusion
• Biological sibling
• Ages 8-28 (when more than one sibling is available the one closest in age will be chosen.))

You may not qualify if…

• Uncontrolled medical conditions that could interfere with participation or interpretation of results
• History of relapsed ALL or history of bone marrow transplantation

Where it is running

• Johns Hopkins Hospital — Baltimore, Maryland, United States
• Sidney Kimmel Comprehensive Cancer Center — Baltimore, Maryland, United States

Full record on ClinicalTrials.gov

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