Can Short Latency Afferent Inhibition Give us Clues to Better DYT 1 Dystonia Treatments?
Completed
Conditions studied: DYT-1, DYT1, DYT 1, Dystonia
In brief
This is a research study using transcranial magnetic stimulation (TMS) to investigate interactions between the sensory system and the motor cortex in primary generalized dystonia (DYT1 dystonia) subjects who undergo deep brain stimulation (DBS) surgery. The sensory system is the body's sense organs - smell, sight, sound, etc. - and the motor cortex is the part of your brain where nerve impulses control voluntary muscle activity.
Key facts
- Study ID
- NCT01435681
- Run by
- University of Florida
- People needed
- 5
- Starts
- 2012-05-01
- Expected to finish
- 2016-08-01
- Last updated by the study team
- 2016-09-08
Who can join
Age: 10 and older, up to 80. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Between the ages of 10 and 80 years. (CONTROL SUBJECTS between 18-80 years)
- Diagnosis and genetic test results confirming diagnosis of DYT1 dystonia.
- Currently treated with medications and enrolled in evaluation process for DBS surgery to confirm candidacy - OR -
- Previous DBS surgery
You may not qualify if…
- Implanted pacemaker, medication pump, vagal stimulator, Transcutaneous electrical nerve stimulation (TENS) unit or ventriculoperitoneal shunt.
- Family or personal history of medication refractory epilepsy.
- Pregnancy: due to the frequent visits over a prolonged period and the lack of Information on the safety of TMS during pregnancy, pregnant women will not be eligible to participate in this study. Women of childbearing potential will be eligible to participate, provided that they are using adequate contraception during TMS treatments.
- This study is accepting healthy volunteers, aged 18-80, as control subjects. Control subjects will not undergo DBS surgery.
- EXCLUSION CRITERIA (as it applies to healthy control subjects):
- Cannot have family history or personal history of medication refractory epilepsy
Where it is running
- UF Center for Movement Disorders and Neurorestoration — Gainesville, Florida, United States
Full record on ClinicalTrials.gov
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