Exertional Heat Illness: Biomarkers for Prediction and Return to Duty

Completed

Conditions studied: Heat Illness

In brief

The investigators goal is to monitor and quantify the differential physiologic and biomarker responses of controls to standardized exercise under thermoneutral and thermally challenged conditions and responses of exertional heat stroke (EHS) subjects under a thermal-challenged environment to develop unique bio-signature panels to predict those at risk for exertional heat illness (EHI) and guide return to duty following an episode of EHS.

Key facts

Study ID

NCT01434979

Run by

Henry M. Jackson Foundation for the Advancement of Military Medicine

People needed

148

Starts

2011-07-01

Expected to finish

2016-02-01

Last updated by the study team

2019-10-11

Who can join

Age: 18 and older, up to 45. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Federal Civilian Employee, Active Duty, or DoD Beneficiary
• Between the ages of 18 and 45 years
• Waist circumference ≤ 39.4 inches (100 cm)
• Willing to walk/run on a treadmill
• Willing to undergo exposure in a thermal chamber
• Willing to maintain their current activity patterns, and to abstain from alcohol, caffeine, and tobacco for 24 hours prior to all sessions
• For cases who have suffered from a exertional heat illness / exertional heat stroke, must have a clinically documented heat stroke within the past year

You may not qualify if…

• History of malignant hyperthermia
• Pregnant or lactating
• Have overt heart disease
• Have systolic blood pressure over 140 mm Hg, or diastolic pressure over 90 mm Hg
• Have a waist circumference > 39.4 inches (100 cm)
• Are older than 45 or younger than 18 years of age
• Are anemic
• Are taking psychotropic medication for any mental health disorder
• Are taking other selected medications (glucose lowering, prednisone or beta blockers)

Where it is running

• Uniformed Services University of the Health Sciences — Bethesda, Maryland, United States
• Heller Institute of Medical Research — Tel Litwinsky, Israel

Full record on ClinicalTrials.gov

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