DNA Analysis in Samples From Younger Patients With Germ Cell Tumors and Their Parents or Siblings
Completed
Conditions studied: Childhood Malignant Ovarian Germ Cell Tumor, Childhood Malignant Testicular Germ Cell Tumor, Ovarian Choriocarcinoma, Ovarian Embryonal Carcinoma, Ovarian Mixed Germ Cell Tumor, Ovarian Teratoma, Ovarian Yolk Sac Tumor, Testicular Choriocarcinoma, Testicular Embryonal Carcinoma, Testicular Seminoma, Testicular Teratoma, Testicular Yolk Sac Tumor
In brief
This research trial studies deoxyribonucleic acid (DNA) samples from younger patients with germ cell tumor and their parents or siblings. Studying samples of tumor tissue and saliva from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
Key facts
- Study ID
- NCT01434355
- Run by
- Children's Oncology Group
- People needed
- 932
- Starts
- 2011-11-01
- Expected to finish
- 2016-08-04
- Last updated by the study team
- 2019-01-07
Who can join
Age: any, up to 19. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- The patient is enrolled on COG-ACCRN07
- The patient has a primary diagnosis of germ cell tumor (GCT) including germinoma (ICCC 9060-9065) teratoma (9080-9084), embryonal carcinoma (9070-9072), yolk sac tumor (9071),choriocarcinoma (9100, 9103, 9104), and mixed GCT (9085, 9101, 9102, 9105) in all sites including the brain and central nervous system and registered with Children's Oncology Group (COG) by a North American member institution
- The patient must be diagnosed with a germ cell tumor between July 1, 2008 and December 31, 2015
- The patient must be < 20 years of age at the time of diagnosis
- The patient must have at least one biological parent alive and willing to participate
- In the event that one case parent cannot contribute DNA, a case sibling, defined as the biological brother or sister of the study subject, may donate instead
- All questionnaire respondents must understand English or Spanish
- Concomitant treatment on a therapeutic trial is not required
Where it is running
- Childrens Oncology Group — Philadelphia, Pennsylvania, United States
Full record on ClinicalTrials.gov
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