Ampicillin for DYT-1 Dystonia Motor Symptoms

Completed · Phase 1 · Has a placebo group

Conditions studied: DYT-1, Dystonia

In brief

The purpose of this study is to evaluate if the antibiotic Ampicillin is safe and tolerated in patients that have generalized dystonia caused by the DYT-1 gene mutation, as compared to patients treated with a placebo. A placebo is a pill that looks and tastes the same as the real drug, but without the active ingredient. The second objective of this study is to determine if dystonia symptoms improve while on the study drug.

Key facts

Study ID

NCT01433757

Run by

University of Florida

People needed

2

Starts

2011-09-01

Expected to finish

2017-06-01

Last updated by the study team

2017-07-05

Who can join

Age: 7 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• DYT-1 dystonia, confirmed by genetic testing
• Between ages of 7 and 80 years
• BFM-DRS score greater than 6

You may not qualify if…

• Negative DYT-1 dystonia gene test
• Allergy to penicillins or cephalosporins
• Concurrent bacterial, viral or fungal infection at time of enrollment
• Pregnancy
• Inability to follow study protocol
• Lactose intolerance (placebo contains lactose powder)

Where it is running

• UF Center for Movement Disorders and Neurorestoration — Gainesville, Florida, United States

Full record on ClinicalTrials.gov

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