Muscle Biopsies in Healthy Volunteers
Stopped early · Not applicable
Conditions studied: Sarcopenia, Frailty, Aging
In brief
Background: \- In individuals as they age, changes in muscle tissue can significantly affect their muscle strength and exercise endurance. This process, known as sarcopenia, may lead to decreased mobility and physical weakness, which is what we in general refer to as frailty. The causes of sarcopenia and why it affects some individuals more than others are not known, but many factors influence muscle physiology and function, including metabolic, hormonal, environmental, and lifestyle factors. Researchers interested in identifying factors involved in the start and progression of sarcopenia need of samples of human muscle tissue and cells for laboratory investigations. Objectives: * To train researchers in the appropriate procedures for performing muscle biopsies and collecting, labeling, and storing the samples. * Develop a data base of specific scientific studies evaluating the physiological and metabolic function of muscle that can be used in future studies. Eligibility: \- Healthy volunteers at least 18 years of age. Design: * Participants will be screened with a full medical history and physical examination, as well as blood and urine tests, and will schedule a date for the muscle biopsy. * Participants will have a muscle biopsy, with tissue and cells taken from the upper part of the thigh. A local anesthetic will be given for the procedure. Participants will also provide a blood sample and have an electrocardiogram to evaluate heart function. * Participants will have a followup visit 1 week after the biopsy visit to evaluate the healing process and provide any further treatment for the affected area, after which they may fully resume normal activities.
Key facts
- Study ID
- NCT01431677
- Run by
- National Institute on Aging (NIA)
- People needed
- 22
- Starts
- 2010-05-17
- Expected to finish
- 2014-07-29
- Last updated by the study team
- 2019-12-17
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
You may not qualify if…
- No history of bleeding diathesis
- Subject is not on heparin, coumadin, plavix, or other anticoagulant
- Subjects taking aspirin or non-steroidal anti-inflammatory agents must stop these 7 days before the biopsy
- No allergy to lidocaine or bupivacaine
- Subject has no active infections or chronic skin conditions that prevent access to the biopsy area
- Unable to provide informed consent
- No antibiotics for the past week
- Positive pregnancy test
- Positive for HIV, and/or positive for hepatitis B or C
Where it is running
- National Institute of Aging, Clinical Research Unit — Baltimore, Maryland, United States
Full record on ClinicalTrials.gov
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