Wake Therapy in the Treatment of Depression
Completed · Not applicable
Conditions studied: Major Depressive Disorder, Bipolar Disorder
In brief
This pilot study seeks to replicate previous findings that sleep deprivation results in marked improvement in depression symptoms, as well as to test whether concurrent treatment with Light Therapy and Lithium are successful in locking in and maintaining therapeutic effects in both bipolar and unipolar depressed subjects.
Key facts
- Study ID
- NCT01431573
- Run by
- New York State Psychiatric Institute
- People needed
- 8
- Starts
- 2011-07-01
- Expected to finish
- 2016-08-01
- Last updated by the study team
- 2021-03-18
Who can join
Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- current major depressive episode (MDD, BP-I or BP-II)
- if not BP-I or BP-II, treatment refractory to ≥ 2 adequately used antidepressants having different mechanisms
- If BP-I or BP-II, treatment refractory to ≥ 1 standard treatment, such as lithium or valproate
- physically healthy
- age 18-75
- not taking current antidepressants(antidepressants deemed effective will not be discontinued
You may not qualify if…
- medically unstable condition
- past intolerance of lithium (bipolar only)
- history of (or current) psychosis or epilepsy
- current (past six months) drug or alcohol abuse/dependence
- pregnancy
- contraindication to lithium (bipolar only)
- significant retinal pathology (e.g., retinitis pigmentosa, macular degeneration)
- currently taking effective antidepressant
- cognitive dysfunction
- Parkinson's Disease
- Thyroid Stimulating Hormone > 5 milli International Units/Liter
- left ventricular hypertrophy
- symptomatic mitral valve prolapse
- abnormal creatinine
Where it is running
- Depression Evaluation Service - New York State Psychiatric Institute — New York, New York, United States
- New York State Psychiatric Institute — New York, New York, United States
Full record on ClinicalTrials.gov
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