Augmenting Language Therapy for Aphasia: Levodopa

Completed · Phase 2/Phase 3 · Has a placebo group

Conditions studied: Nonfluent Aphasia, Stroke

In brief

The purpose of this study is to evaluate the effectiveness of the medication levodopa, in combination with speech-language treatment, on the language outcome of study subjects with nonfluent aphasia (i.e. difficulty with the comprehension and expression of spoken and written language) following a stroke.

Key facts

Study ID

NCT01429077

Run by

Shirley Ryan AbilityLab

People needed

36

Starts

2007-10-01

Expected to finish

2012-03-01

Last updated by the study team

2013-12-25

Who can join

Age: 21 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• A single unilateral left-hemisphere stroke
• Nonfluent aphasia, with a mean length of utterance of 0-4 words and an Aphasia Quotient between 20 and 75 on the Western Aphasia Battery
• Age 21 or older.
• At least 6 months post-stroke
• Able to comply with the study protocol
• Premorbidly right-handed, as determined by the Edinburgh Handedness Inventory
• Fluent in English premorbidly
• Completed at least 8th grade education

You may not qualify if…

• More than one stroke
• Any other neurological condition that could potentially affect cognition or speech.
• Global aphasia or inability to participate in routine speech therapy.
• Major active psychiatric illness that may interfere with required study procedures.
• Untreated or inadequately treated depression.
• Has started taking a potentially confounding central nervous system (CNS) drug within the previous 2 months.
• Current abuse of alcohol or drugs
• Nursing a child or pregnant
• Participation in another drug, device or biologics trial within the preceding 90 days
• Unable to understand, cooperate or comply with study procedures
• Significant visual or auditory impairment
• History of sensitivity to ergot derivatives.
• Active medical illness or current medication that precludes safe participation in this study.

Where it is running

• Center for Aphasia Research & Treatment — Chicago, Illinois, United States

Full record on ClinicalTrials.gov

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